Cambridge Healthtech Institute第3屆

Oncolytic Virus Immunotherapy

( 溶瘤病毒免疫療法 )

具備莫大潛力的溶瘤病毒免疫療法商業化

2018年8月27日~28日

本單元以溶瘤病毒免疫療法為主題,在藥廠及研究機關擔任指導性角色的研究人員將齊聚一堂,討論加速使用溶瘤病毒免疫療法開發的重要步驟,另將介紹運送及併用療法的策略、病毒的開發、產品相關重要情報。

Coverage will include, but is not limited to:

Latest updates and future directions in oncolytic virus immunotherapy

  • Update on recent deals, science and collaborations - what are the market dynamics - types of viruses (Herpes, Adeno, Vaccinia)
  • Feedback from big pharma, Pfizer, Amgen's post T-Vec OV portfolio
  • What needs to happen to take OVs forward
  • Update from companies with late-stage products/approvals - post-market approvals

Oncolytics in an era of combination therapies

  • Are combinations the only way forward for oncolytics?
  • Examples of successful combination models - checkpoints, CAR Ts, kinase inhibitors, alternative to checkpoints, antibodies
  • Issues when combining OVs - feedback on trials
  • Evidence to support role of oncolytics as monotherapies?

Improving OV potency, targeting and efficacy

  • Engineering strategies to improve efficacy and specificity - highly armed OVs
  • New virus, mechanism of actions
  • Tumor targeted delivery - latest from Ignite
  • Impact of tumor microenvironment - vascularization

Improving delivery and administration

  • Oncolytics as a single shot vs. multiple shots - mechanisms of action, evidence-based medicine
  • IV vs. systemic - dosage, delivery, delivery when combining with PD-1s
  • Evidence to support systemic route, what data is available

Oncolytics in development: Update on major clinical and preclinical therapies

  • Clinical updates - results, safety, efficacy issues, patient selection, setting endpoints, presenting data to physicians
  • Lessons learned in the clinic - translational strategies, novel preclinical models, biomarkers
  • Regulatory expectations -what to submit to regulators, data to include, feedback

* 活動內容有可能不事先告知作更動及調整。

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