Exponential increases in demand for the next generation of clinical diagnostic, monitoring and measuring sensors for applications in implantable and wearable devices have created new commercial market opportunities with extensive growth potential. Low-cost materials and advances in nano and micro fabrication techniques within the manufacturing process have led to significant increases in the commercialization of biological sensors for healthcare applications. This conference will examine the latest advancements in research, engineering and commercialization and will provide attendees with the state-of-the-art in next-generation biosensors for healthcare.
7:30 am Registration and Morning Coffee
8:00 Chairperson's Remarks
Craig Wohlers, Executive Director, Conferences, Cambridge Innovation Institute
8:10 AI to the Rescue: Curing and Augmenting Brain Capabilities with the Smart Kiwi Nano-Implant
Brain Computer Interface technologies are in constant improvement with interaction modalities ranging from non-invasive (EEG, TMS, etc.) to chronically implanted devices. We are presenting here Kiwi, a novel, minimally invasive micro-implant using nanotechnologies to record the electrical activity of neural tissue and stimulate using electrical and optical stimulation modalities. Kiwi micro-implant is operating wirelessly and is coupled to a cutting-edge AI module providing the possibility to detect in real-time neural activity patterns and adjust the stimulation parameters accordingly. This adaptative, minimally invasive and smart BCI opens a new way for personalized therapeutic applications in numerous diseases such as neurodegenerative diseases (Parkinsons, Alzheimers, etc.), mental illnesses (depression, anxiety, etc.) or chronic pain, brain augmentation, and research device.
8:35 PANEL DISCUSSION: Sensor Mergers & Acquisitions: Models for Success and Lessons from Failures
This panel discussion will examine the current landscape of mergers and acquisitions with the sensors and device space. Our panel of experts will discuss the current outlook within the marketplace and will examine past success and failures and how the pitfalls of failure can be avoided.
9:25 Coffee Break in the Exhibit Hall with Poster Viewing
Advanced Biosensor Design, Materials & Engineering
9:55 Chairperson's Remarks
Marcie Black, PhD, CEO, Advanced Silicon Group
10:00 Micro Raman Sensing for Cancer Applications
Novel approaches toward understanding disease can enable better management of disease progression and evaluation. Raman spectroscopy is a diagnostic tool that can assist in uncovering the molecular basis of disease and provide quantifiable molecular information for diagnosis. This presentation will review the state-of-the-art micro Raman spectroscopy sensing of cancer utilizing the power of Deep Learning algorithms for near instantaneous diagnosis in the clinical setting.
10:30 Engineering in Medical Diagnostics and Therapeutics: New Treatment Options for Gastric Cancer
Modern medicine depends on combined efforts of engineers and biologists. We tested a plant metabolite Gallic Acid (GA) as an alternative treatment for gastric cancer, one of the deadliest worldwide. Using MEMS sensors, DNA microchip arrays, and molecular biology techniques we identified the likely target for the treatment and evaluated its efficiency. We demonstrated the GA ability to reverse malignant transformation in cell culture.
11:00 Nanosensors for 30-Second Handheld Pathogen Detection
Pinpoint Science offers unique nanosensor technology for low-cost detection of viral, bacterial and fungal pathogens in seconds, with detection levels below 500 femtograms/ml. This unique diagnostic platform can use antibodies, oligos, aptamers and nanobodies for rapid, label-free bioelectronic detection and quantification of pathogens in point-of-care settings.
11:30 Electrochemical Sensors and Systems for Wearable and Minimally Invasive Healthcare Applications
This presentation will describe some emerging electrochemical sensors and systems to address the challenges of continuous real-time monitoring of selected biomarkers for wearable and minimally invasive medical devices. Challenges which will be discussed will include sensor and instrumentation design, sensor biocompatibility, how to prevent biofouling impacting on performance, form factor of the system, etc. Some exemplars of the emerging systems will be showcased.
12:00 pm Reliability Learnings and Benefits from Operational In-Situ Sensor Testing
Sensors used in consumer devices are becoming more complex and more custom. Assessing sensor reliability is now a challenging task, custom sensors have several critical blocks and assessing each and every block is required to accurately assess sensor reliability. Here we will present a sample example on how in-situ operational sensor testing is beneficial in identifying additional failure modes which would have otherwise missed if traditional passive reliability test methodologies and procedures were to be followed.
12:30 Enjoy Lunch on Your Own
Market and the Path to Commercialization
Advanced Biosensor Design, Materials & Engineering
2:00 Sensors for Health Analysis from Exhaled Breath
Since breath alcohol measuring devices became handheld, many companies have tried to replicate this success for other conditions and disease- with no success. The problem has proven to be high variability, sample contamination risks, and even sample loss- all contributing to unreliable data, even with 35-pound desktop instruments. We have addressed these three problems specifically by developing a new, handheld breath capture device. Our preliminary data further show that our solution is capable of detecting and analysing microorganisms living deep in the lung, in a fully non-invasive manner. The patent-protected technology has utility beyond human/veterinary healthcare and well-being in the biodefence, environmental monitoring, agritech and food sectors.
2:30 Silicon Nanowire Biosensors
We present Advanced Silicon Group’s nanowire biosensor which enables low cost, multiplexed, and rapid detection of proteins and DNA using one test. The nanowires make the sensor more sensitive to its environment allowing detection of dilute solutions. Our vision is to make diagnostics rapid, easy to use, and low cost so that everyone has access to good healthcare.
3:00 Refreshment Break in the Exhibit Hall with Poster Viewing
3:30 Wearable, Novel, Optical Sensor for Continuous Noninvasive Blood Pressure (cNIBP) Monitoring
ViTrack™ is a first-of-its-kind, cuff-less, wearable, standalone technology for cNIBP monitoring, which includes a novel optical sensor capable of 3D contact sensing at microscale. The wrist wearable ViTrack™ device captures the spatiotemporal force distribution within the contact region of the skin and utilizes a proprietary new methodology to directly measure (self-calibrate) and continuously track systolic and diastolic BP.
4:00 Health and Wellness through Salivary Diagnostics
Noninvasive approach to monitor individual's physiological and pathological state is one of the most desirable goals in healthcare research. The presence of various disease-signaling biomarkers and ease of sampling and storage makes saliva a useful medium of detection. Traq makes cost efficient, accurate and portable biosensors that can track activity and health data using saliva as a medium in real time. Traq products are designed to go anywhere, giving flexibility of where and when you track personal health and wellness data, decreasing the need for hospital and physician office visits. This powerful solution creates a synergy that can change the way we all approach health. Own Your HealthTM. This presentation overviews the clinical importance of saliva as a diagnostic medium and portrays the current research and technology development in Traq.
4:30 AI Powered Sensing for Next-Generation Health-Tracking
Sensing and computing have traditionally been separate functions. Recently, we have seen a trend towards integration of sensing and computing, and with the advent of AI, this trend is accelerating. This talk highlights the benefits of sensing and AI integration for voice activation, context awareness and health-tracking applications.
5:00 Close of Summit