會前研討會 2026年10月19日（星期一） - 日本時間（GMT+09:00)

Today’s wealth of knowledge of antibody structures will be reviewed along with the genetics of diversity generation, to give insights into the best strategies for improving function. There is particular emphasis on the choice of a functional assay to effectively monitor the changes in a desired property, and the use of functional enrichment steps where a library approach is employed. Not only is amino acid sequence amenable to engineering, but glycan structures and other modifications may also be engineered. The course will focus on the engineering and enhancement of antibodies and antibody-like scaffolds. Examples will include work on antibody fragment affinity improvement by 100-fold to low pM affinity. Also, the engineering of bispecific antibodies by diverse approaches and the adaptation to generate Chimeric Antibody Receptor (CAR) constructs will be discussed. Expression platforms for producing antibodies for testing and for manufacture will also be covered. A background in biochemistry and molecular biology is useful, as the course is designed to progress rapidly from simple to advanced concepts.

This workshop covers the key aspects of ADC design, why each piece is important and how each can synergize to make an optimized product. It will give a comprehensive overview of the current state-of-the-art approaches available for ADCs and provides an introductory framework so participants can rapidly identify issues and solutions in their specific projects. It is aimed to provide even beginners with explanations of the nomenclature and science. The teams involved in ADC development need both chemists and biologists to work together effectively. The course provides an opportunity to better understand both aspects of the science and thus enhance communication within your team.